Yes - I have a lot of stuff printed through commercial printers at work - over $150,000 worth this year alone. Printers hate stuff with lots of black and the image quality can suffer.
Look at a high quality catalog or magazine with lots of color images on each page. Very seldom will you see photos with black backgrounds (that look any good.) If the printer adjusts the printer so the subject matter looks the best, the background gets funky. If he adusts the press so the background looks good, the subject can look bad.
SCR editor Pete Piekarski is a professional graphic artist who works with commercial printers even more than I do. He'd be able to give you the real scoop. He is in the middle of the SCR production cycle right now so it might take him a little bit to get back to you. Email him a few sample images at firstname.lastname@example.org